Who are we ?

Inovpain FHU project offers a unique opportunity to build strong and synergistic collaborations and federate clinical practice, research and teaching activities in a comprehensive program. Inovpain is centered on refractory chronic pains, but mainly focused on neuropathic pain and chronic daily headache.



Work Packages

The project is structured around 6 complementary Work Packages (WP) conducted in parallel . Tight collaboration between clinicians and researchers is essential for a rapid transfer of new fundamental knowledge into clinical practice and personalized healthcare, and to stimulate research from clinical questions.



The consortium

INOVPAIN is based on effective interactions between clinical teams, academic research teams and industrial partners. Several scientific and health care platforms are involved as well. Altogether, the INOVPAIN project will propose a multidisciplinary, synergistic and regionally organized network focusing on refractory chronic pains.



New mechanism causing migraines discovered by FHU team member

Researchers at CNRS, Université Côte d’Azur and Inserm have demonstrated a new mechanism related to the onset of migraine. They found that a genetic mutation induces dysfunction in a protein which inhibits neuronal electrical activity, causing migraines. These results, published in Neuron on December 17, 2018, open a new path for the development of anti-migraine treatments.

Read more.

Neurosurgery workshop - Occipital Nerve Stimulation

According to its objectives, FHU INOVPAIN organized a special workshop on  18/10/2018. FHU team received colleagues from Lille, Marseille and Paris in order to train them to occipital nerve stimulation (ONS).

This technique consists to apply a continuous electrical stimulation to the great and/or lesser occipital nerve through a subcutaneous chronically implanted electrode close to the nerve and connected to a generator. ONS induces paresthesia in the occipital region and has been proposed initially to control occipital neuralgia and then to treat primary headaches.


Video Abstract - "Dural and pial pain-sensitive structures in humans: new inputs from awake craniotomies"

Denys Fontaine, Fabien Almairac, Serena Santucci, Charlotte Fernandez, Radhouane Dallel, Johan Pallud, Michel Lanteri-Minet

2018 Jan 29. doi: 10.1093/brain/awy005

FHU members latest publications

  1. Bendtsen, L, Zakrzewska, JM, Abbott, J, Braschinsky, M, Di Stefano, G, Donnet, A et al.. EAN guideline on trigeminal neuralgia. Eur. J. Neurol. 2019; :. doi: 10.1111/ene.13950. PubMed PMID:30860637 .
  2. Donnet, A, Emery, C, Aly, S, Allaf, B, Cayre, F, Mahieu, N et al.. Migraine burden and costs in france: a nationwide claims database analysis of triptan users. J Med Econ. 2019; :1. doi: 10.1080/13696998.2019.1590841. PubMed PMID:30836035 .
  3. Perrot, S, Lantéri-Minet, M. Patients' Global Impression of Change (PGIC) in the Management of Peripheral Neuropathic Pain: Clinical Relevance and Correlations in Daily Practice. Eur J Pain. 2019; :. doi: 10.1002/ejp.1378. PubMed PMID:30793414 .
  4. Welter, ML, Houeto, JL, Worbe, Y, Diallo, MH, Hartmann, A, Tezenas du Montcel, S et al.. Long-term effects of anterior pallidal deep brain stimulation for tourette's syndrome. Mov. Disord. 2019; :. doi: 10.1002/mds.27645. PubMed PMID:30788865 .
  5. Corti, A, Sota, R, Dugo, M, Calogero, RA, Terragni, B, Mantegazza, M et al.. DNA damage and transcriptional regulation in iPSC-derived neurons from Ataxia Telangiectasia patients. Sci Rep. 2019;9 (1):651. doi: 10.1038/s41598-018-36912-0. PubMed PMID:30679601 PubMed Central PMC6346060.
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