Who are we ?
Inovpain FHU project offers a unique opportunity to build strong and synergistic collaborations and federate clinical practice, research and teaching activities in a comprehensive program. Inovpain is centered on refractory chronic pains, but mainly focused on neuropathic pain and chronic daily headache.
The project is structured around 6 complementary Work Packages (WP) conducted in parallel . Tight collaboration between clinicians and researchers is essential for a rapid transfer of new fundamental knowledge into clinical practice and personalized healthcare, and to stimulate research from clinical questions.
INOVPAIN is based on effective interactions between clinical teams, academic research teams and industrial partners. Several scientific and health care platforms are involved as well. Altogether, the INOVPAIN project will propose a multidisciplinary, synergistic and regionally organized network focusing on refractory chronic pains.
New mechanism causing migraines discovered by FHU team member
Researchers at CNRS, Université Côte d’Azur and Inserm have demonstrated a new mechanism related to the onset of migraine. They found that a genetic mutation induces dysfunction in a protein which inhibits neuronal electrical activity, causing migraines. These results, published in Neuron on December 17, 2018, open a new path for the development of anti-migraine treatments.
FHU INOVPAIN participated in this important event by organizing a special Neuroscience Day at Nice University Hospital presenting medical procédures, new therapeutics and innovations to the public.
FHU members latest publications
- Desroches, M, Faugeras, O, Krupa, M, Mantegazza, M. Modeling cortical spreading depression induced by the hyperactivity of interneurons. J Comput Neurosci. 2019; :. doi: 10.1007/s10827-019-00730-8. PubMed PMID:31620945 .
- Royal, P, Sandoz, G. [Ion channels and mechanisms of inherited disease transmission causing migraine]. Med Sci (Paris). ;35 (8-9):608-610. doi: 10.1051/medsci/2019121. PubMed PMID:31539490 .
- Bonnet, C, Hao, J, Osorio, N, Donnet, A, Penalba, V, Ruel, J et al.. Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache. Nat Commun. 2019;10 (1):4253. doi: 10.1038/s41467-019-12197-3. PubMed PMID:31534133 PubMed Central PMC6751217.
- Léna, I, Mantegazza, M. NaV1.2 haploinsufficiency in Scn2a knock-out mice causes an autistic-like phenotype attenuated with age. Sci Rep. 2019;9 (1):12886. doi: 10.1038/s41598-019-49392-7. PubMed PMID:31501495 PubMed Central PMC6733925.
- Redon, S, Donnet, A. Dramatic Response to Nebivolol in an Adult Case of Cyclic Vomiting Syndrome. Headache. 2019;59 (10):1827-1828. doi: 10.1111/head.13619. PubMed PMID:31444886 .