Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK.

Neuron. 2019 Jan 16;101(2):232-245.e6. doi: 10.1016/j.neuron.2018.11.039. Epub 2018 Dec 17. Royal P1, Andres-Bilbe A2, Ávalos Prado P1, Verkest C3, Wdziekonski B1, Schaub S4, Baron A5, Lesage F3, Gasull X2, Levitz J6, Sandoz G7. Abstract It is often unclear why some

Effects of systemic inhibitors of Acid-Sensing Ion Channels 1 (ASIC1) against acute and chronic mechanical allodynia in a rodent model of migraine.

Br J Pharmacol. 2018 Nov;175(21):4154-4166. doi: 10.1111/bph.14462. Epub 2018 Sep 22. Verkest C1,2,3, Piquet E3,4, Diochot S1,2,3, Dauvois M1, Lanteri-Minet M3,4,5, Lingueglia E1,2,3, Baron A1,2,3. Abstract BACKGROUND AND PURPOSE: Acid-sensing ion channels (ASICs) are neuronal proton sensors emerging as potential

Gain of Function for the SCN1A/hNav1.1-L1670W Mutation Responsible for Familial Hemiplegic Migraine.

Front Mol Neurosci. 2018 Jul 9;11:232. doi: 10.3389/fnmol.2018.00232. eCollection 2018. Dhifallah S1, Lancaster E2, Merrill S2, Leroudier N1, Mantegazza M1, Cestèle S1. Author information Abstract The SCN1A gene encodes for the voltage-dependent Nav1.1 Na+ channel, an isoform mainly expressed in

Efficacy and safety of a T-type calcium channel blocker in patients with neuropathic pain: A proof-of-concept, randomized, double-blind and controlled trial.

Eur J Pain. 2018 Aug;22(7):1321-1330. doi: 10.1002/ejp.1221. Epub 2018 Apr 18. Kerckhove N1,2, Pereira B1, Soriot-Thomas S3, Alchaar H4, Deleens R5, Hieng VS6, Serra E3, Lanteri-Minet M1,4, Arcagni P7, Picard P1, Lefebvre-Kuntz D8, Maindet C9, Mick G10, Balp L11, Lucas

Development of the First Two-Pore Domain Potassium Channel TWIK-Related K+ Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity.

J Med Chem. 2017 Feb 9;60(3):1076-1088. doi: 10.1021/acs.jmedchem.6b01285. Epub 2017 Jan 20. Vivier D1, Soussia IB2, Rodrigues N1, Lolignier S3, Devilliers M3, Chatelain FC2, Prival L3, Chapuy E3, Bourdier G1, Bennis K1, Lesage F2, Eschalier A3,4, Busserolles J3, Ducki S1.

Analgesic effects of mambalgin peptide inhibitors of acid-sensing ion channels in inflammatory and neuropathic pain.

Pain. 2016 Mar;157(3):552-9. doi: 10.1097/j.pain.0000000000000397. Analgesic effects of mambalgin peptide inhibitors of acid-sensing ion channels in inflammatory and neuropathic pain. Diochot S1, Alloui A, Rodrigues P, Dauvois M, Friend V, Aissouni Y, Eschalier A, Lingueglia E, Baron A. Abstract Mambalgins