Dr Eric Lingueglia

Institut de Pharmacologie Moléculaire et Cellulaire

660 Route des Lucioles
SOPHIA ANTIPOLIS
06560 VALBONNE

Team Ion channel and pain

Chronic pain is a major health problem that substantially reduces quality of life, affecting about 20% of adults and up to 50% of the elders. However, currently approved analgesics are often associated with poor tolerability, low compliance due to side effects, and concerns over long-term safety and abuse potential. Most pain therapeutics approved in the last decade are just new formulations of existing drugs, in part because of poor understanding of the underlying pathophysiology. In this context, the discovery of new drug targets represents a real opportunity for developing new strategies against pain.

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Acid-Sensing Ion Channels (ASICs), which form excitatory (depolarizing) cation channels activated by extracellular protons, and two pore domain background K+ channels (K2Ps), which form inhibitory (hyperpolarizing) potassium channels, are novel molecular targets for pain identified in recent years.

- Properties and regulation of ASIC channels - pathophysiological implications in pain (coordinator: E Deval).
- Pharmacology and structure/function relationships of ASIC channels (coordinator: E Lingueglia).
- Pathophysiology of K2P channels in pain (coordinator: J Noël).


Work Packages

Discover the main work modules of Inovpain FHU.


Research Teams

Several academic research teams participate in the INOVPAIN project.


Want to know more about pain ?

Find informations by visiting these websites.

Recent works

  1. Verkest, C, Piquet, E, Diochot, S, Dauvois, M, Lanteri-Minet, M, Lingueglia, E et al.. Effects of systemic inhibitors of acid-sensing ion channels 1 (ASIC1) against acute and chronic mechanical allodynia in a rodent model of migraine. Br. J. Pharmacol. 2018;175 (21):4154-4166. doi: 10.1111/bph.14462. PubMed PMID:30079481 PubMed Central PMC6177611.
  2. Besson, T, Lingueglia, E, Salinas, M. Pharmacological modulation of Acid-Sensing Ion Channels 1a and 3 by amiloride and 2-guanidine-4-methylquinazoline (GMQ). Neuropharmacology. 2017;125 :429-440. doi: 10.1016/j.neuropharm.2017.08.004. PubMed PMID:28802647 .
  3. Aissouni, Y, El Guerrab, A, Hamieh, AM, Ferrier, J, Chalus, M, Lemaire, D et al.. Acid-Sensing Ion Channel 1a in the amygdala is involved in pain and anxiety-related behaviours associated with arthritis. Sci Rep. 2017;7 :43617. doi: 10.1038/srep43617. PubMed PMID:28321113 PubMed Central PMC5340794.
  4. Besson, T, Debayle, D, Diochot, S, Salinas, M, Lingueglia, E. Low cost venom extractor based on Arduino(®) board for electrical venom extraction from arthropods and other small animals. Toxicon. 2016;118 :156-61. doi: 10.1016/j.toxicon.2016.05.001. PubMed PMID:27158113 .
  5. Marra, S, Ferru-Clément, R, Breuil, V, Delaunay, A, Christin, M, Friend, V et al.. Non-acidic activation of pain-related Acid-Sensing Ion Channel 3 by lipids. EMBO J. 2016;35 (4):414-28. doi: 10.15252/embj.201592335. PubMed PMID:26772186 PubMed Central PMC4755115.
  6. Mourier, G, Salinas, M, Kessler, P, Stura, EA, Leblanc, M, Tepshi, L et al.. Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition. J. Biol. Chem. 2016;291 (6):2616-29. doi: 10.1074/jbc.M115.702373. PubMed PMID:26680001 PubMed Central PMC4742732.
  7. Diochot, S, Alloui, A, Rodrigues, P, Dauvois, M, Friend, V, Aissouni, Y et al.. Analgesic effects of mambalgin peptide inhibitors of acid-sensing ion channels in inflammatory and neuropathic pain. Pain. 2016;157 (3):552-9. doi: 10.1097/j.pain.0000000000000397. PubMed PMID:26492527 .
  8. Lingueglia, E, Lazdunski, M. Acid-Sensing Ion Channels in the nervous system. Foreword. Neuropharmacology. 2015;94 :1. doi: 10.1016/j.neuropharm.2015.03.011. PubMed PMID:25813612 .
  9. Deval, E, Lingueglia, E. Acid-Sensing Ion Channels and nociception in the peripheral and central nervous systems. Neuropharmacology. 2015;94 :49-57. doi: 10.1016/j.neuropharm.2015.02.009. PubMed PMID:25724084 .
  10. Baron, A, Lingueglia, E. Pharmacology of acid-sensing ion channels - Physiological and therapeutical perspectives. Neuropharmacology. 2015;94 :19-35. doi: 10.1016/j.neuropharm.2015.01.005. PubMed PMID:25613302 .
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News

Latetest scientific articles about chronic pain.