The INOVPAIN project is structured around 6 complementary Work Packages (WP) conducted in parallel. Emphasis is put on the need of a tight collaboration between clinicians and researchers for a rapid transfer of new fundamental knowledge into clinical practice and personalized healthcare, and to stimulate research from clinical questions.

Care, Evaluation and Database (wp1) aims at developing a comprehensive multidimensional rCP assessment, at selecting the best therapeutic options, and at building a shared database to  ollow-up this carefully studied cohort of rCP patients.

Biomarkers (wp2) aims at identifying biomarkers of pain chronicity and treatment-resistance. It strongly interacts with WP1.

Neuromodulation (wp3)  to develop and diffuse therapeutic solutions using “neuromodulation” for rCP patients, namely surgical techniques using electrical stimulation of the nervous system.

Pharmacological Therapies (wp4) focus on pharmacological solutions, through understanding the mechanisms of treatment resistance and development of new analgesic drugs.

Connected Tools (wp5) develops new technologies and connected tools that can be use to improve rCP patient’s evaluation, treatment and education.

Education (wp6) aims at promoting and disseminating the translational approach of INOVPAIN among the students, health professionals, patients, the greater public and policy makers; it therefore benefits directly from the achievements in the WP1 through 5.

These work packages interact together and show how the INOVPAIN project proposes a multidiscplinary, complementary, synergistic and regionally organized network focused on refractory chronic pain management and research.